和平精英服饰币在哪用:mutaFISH? (mutation-specific Fluorescence In Situ Hybridization)
Single Cell, Single Molecule, DNA and RNA Mutation Detection at Single Nucleotide Resolution
The ability to interrogate cellular heterogeneity at the single cell and single molecule levels has gained increased importance. Many bioreagents and techniques exist to address this issue separately. None has the unified approach to detect and quantify DNA and RNA changes across diverse spectrum particularly point mutations and single-nucleotide polymorphisms (SNP) while maintaining their spatial context. This challenge is even greater as different analytical platforms such fluorescence, cyto/histochemistry, flow cytometry, and microfluidics are needed to study the complexity of biological states.
Abnova has integrated padlock probe and rolling circle amplification (RCA) for in situ, single cell, single molecule, DNA and RNA mutation detection at single nucleotide resolution, and obviated the technical challenges of PCR and hybridization optimization required for efficient and target-specific analysis. Abnova provides a growing portfolio of off-the-shelf, validated mutaFISH? probes and accessory reagents to address the unmet needs in the research and clinical settings.